The Heart and Soul Study is a prospective cohort study that was designed to determine how depression and other mental health conditions influence the outcomes of patients with coronary heart disease.
A total of 1024 participants were enrolled between September 01, 2000 and December 31, 2002 and followed for an average of 10 years.
The Heart and Soul Study found that depressive symptoms were more strongly associated with health-related quality of life than objective measures of cardiac disease severity in patients with existing coronary heart disease (JAMA, 2003).
The Heart and Soul Study also demonstrated that the excess risk of cardiovascular events associated with depressive symptoms was not explained by the expected biological factors (e.g., increased catecholamine levels or inflammation) but rather by poor health behaviors, such as medication non-adherence and physical inactivity (JAMA, 2008). This finding introduced the possibility that the excess risk of cardiovascular events associated with depression could be preventable with behavior modification.
In addition to evaluating the links between mental and physical health, the Heart and Soul Study has provided a rich dataset for investigators to answer many other important research questions in cardiovascular epidemiology.
- Depressive symptoms and health-related quality of life (JAMA 2003) Abstract PDF
- Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease (JAMA 2008) Abstract PDF
- Diagnosis and treatment of depression in adults with comorbid medical conditions (JAMA 2012) Abstract PDF
- More publications from the Heart and Soul Study